Monday, January 27, 2020

Alfuzosin Hydrochloride and Dutasteride In Tablets

Alfuzosin Hydrochloride and Dutasteride In Tablets ABSTRACT This chapter describes method development and validation of UV First Derivative Zero Crossing method for simultaneous determination of Alfuzosin Hydrochloride and Dutasteride in tablet dosage forms. AIM The main aim of the present study is to develope a simple, sensitive and cost effective UV spectroscopic method for the simultaneous estimation of Alfuzosin Hydrochloride and Dutasteride in tablets, on the basis of zero Crossing measurement. Validation of the developed method for routine analysis of Alfuzosin Hydrochloride and Dutasteride in tablets for quality control laboratories. RATIONALE Alfuzosin Hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Recently both the drugs have been marketed in combination (Alfusin D acts on both the dynamic and the static components of BPH) in tablet dosage forms; combined oral administration has been found to be more effective than either single drug. To the best of knowledge, no derivative spectroscopic method available for simultaneous determination. Derivative spectroscopy provides a greater selectivity than common spectroscopy. RESULT AND CONCLUSION A simple, accurate and precise spectroscopic method was developed for  simultaneous determination of LER and ATE in tablets using first derivative  Zero crossing method. LER shows ZCP at 231 nm while ATE shows ZCP at  250 nm. The 1D amplitude was measured at 250 nm for LER and 231 nm For  ATE and calibration curves were plotted as 1D amplitude versus concentration,  respectively. The method was found to be linear from 4-28 ÃŽÂ ¼g/mL for LER  (r2=0.9967) at 250 nm and 5-30 ÃŽÂ ¼g/mL for ATE (r2=0.9996) at 231 nm. The  within day and between day variations showed coefficient of variation (%CV)  values 1.2 LITERATURE REVIEW 1.2.1 BENIGN PROSTATIC HYPERPLASIA (BPH): It is characterized by hyperplasia of prostatic stromal and epithelial cells, resulting in the formation of large, fairly discrete nodules in the periurethral region of the prostate. When sufficiently large, the nodules compress the urethral canal to cause partial, or sometimes virtually complete, obstruction of the urethra, which interferes the normal flow of urine. It leads to symptoms of urinary hesitancy, frequent urination, dysuria (painful urination), increased risk of urinary tract infections, and urinary retention. Although prostate specific antigen levels may be elevated in these patients because of increased organ volume and inflammation due to urinary tract infections, BPH is not considered to be a premalignant lesion. Adenomatous prostatic growth is believed to begin at approximately age 30 years. An estimated 50% of men have histologic evidence of BPH by age 50 years and 75% by age 80 years. In 40-50% of these patients, BPH becomes clinically significant. How does BPH occur? The prostate goes through two main periods of growth. In early puberty, the prostate doubles in size. Then, around age 25, the prostate begins to grow again and continues to grow throughout most of a mans life. The continuing enlargement of the prostate does not usually cause problems until later in life. However, the second period of growth may, many years later, result in BPH. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): BPH rarely causes symptoms before age 40. More than half of men in their 60s have some symptoms of BPH. As many as 90 percent of men in their 70s and 80s have some symptoms of BPH SYMPTOMS: Difficulty in starting to pass urine ( hesitancy) A weak stream of urine Dribbling after urinating The need to strain to pass urine Incomplete emptying of bladder Difficulty to control the urination urge Having to get up several times in the night to pass urine Feeling a burning sensation when passing urine Passing urine mixed with blood (indication of infection) Treatment of BPH   BPH may not require any form of treatment and may just be monitored for any changes or early signs of any problems. In the event that BPH has caused a urinary tract infection, the infection will be treated first with antibiotic medications and then the BPH may be treated. There are several forms of treatment that can be used for benign prostatic hyperplasia that include medications, minimally invasive therapies, and surgery. The two types of medications currently used to treat BPH are alpha-adrenergic receptor blockers and 5-alpha reductase inhibitors.   These medications can prevent the prostrate gland from growing larger and may shrink the prostrate gland in some patients.   How do Alpha blockers work: Alpha blockers work by relaxing the smooth muscle tissue in your prostate and at the opening to your bladder. When this muscle tissue relaxes, it is easier for your urine to flow. This may help if you have difficulty starting to urinate and a weak urine stream. Alpha blockers can start working within two to three days, and may relieve your urinary symptoms in about two to three weeks. However, these medications do not stop your prostate gland from continuing to enlarge. Available alpha blockers include: Cardura (doxazosin) Flomax (tamsulosin) Hytrin (terazosin) Uroxatral(alfuzosin) How do 5 alpha reductase inhibitors work The 5-alpha reductase inhibitors work by interfering with the effect of specific male hormones (androgens) on your prostate. This may slow the growth of your prostate and can even cause your prostate to get smaller, which may help improve BPH symptoms. Men with larger prostates may have a greater benefit from these medications than do men with smaller prostates. But, for some men, size (of the prostate that is) does not matter, and the 5-alpha reductase inhibitors may not give satisfactory results even if your prostate gets smaller. The 5-alpha reductase inhibitors work slowly, and they may take up to six months before you notice any improvement. Available 5-alpha reductase inhibitors include: Avodart (dutasteride) Proscar (finasteride) Both an Alpha Blocker and 5-alpha Reductase Inhibitor Depending on symptoms and the size of your prostate, your doctor may recommend a combination of an alpha-blocker with a 5-alpha reductase inhibitor. The combination of the two types of medications may help more than either medicine alone. 1.2.2 DRUG PROFILE: Alfuzosin hydrochloride: It is an alpha-adrenergic blocker Structure File:Alfuzosin.svg N-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]propyl] tetrahydrofuran- 2-carboxamide Dutasteride: It is a 5-alpha-reductase inhibitor. Structure File:Dutasteride.svg (5ÃŽÂ ±,17ÃŽÂ ²)-N-{2,5bis(trifluoromethyl) phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide Pharmacodynamic Alfuzosin is a quinazoline-derivative alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, alfuzosin is a selective inhibitor of the alpha(1) subtype of alpha adrenergic receptors. In the human prostate, alfuzosin antagonizes phenylephrine (alpha(1) agonist)-induced contractions Pharmacokinetics  and Metabolism Absorption is 50% lower under fasting conditions Volume of distribution 3.2 L/kg [healthy male middle-aged volunteers] Protein binding 82%-90% Metabolism Hepatic. Alfuzosin undergoes extensive metabolism by the liver, with only 11% of the administered dose excreted unchanged in the urine. Alfuzosin is metabolized by three metabolic pathways: oxidation, O-demethylations, and N-dealkylation. The metabolites are not pharmacologically active. CYP3A4 is the principal hepatic enzyme isoform involved in its metabolism. 1.2.3 REPORTED UV SPECTROPHOTOMETRIC METHODS 1.2.4 Aim and Objective of the present work: Derivative spectroscopic methods are more sensitive than other spectroscopic method according to literature there is no derivative spectroscopic method reported so there is need to develop a sensitive derivative spectroscopic method which is more sensitive than simultaneous equation method so aim is to develop and validate the first derivative Zero-Crossing UV spectrophotometric method and apply that method to simultaneous determination of these drug in marketed formulation. 1.3 EXPERIMENTAL WORK 1.3.1 Chemicals and Reagents Alfuzosin HCl and Dutasteride ALFUSIN D (CIPLA Ltd.) containing 10 mg of Alfuzosin HCl 0.5 mg of Dutasteride were purchased from local market. Methanol of HPLC grade was purchased from Merck Ltd. (Mumbai, India). Purified Water was prepared using a Millipore Milli-Q system (Bedford, MA, USA). 1.3.2 Instrument Spectroscopic Analysis was carried out on a JascoV-650 double beam UV-Visible  spectrophotometer with software of Spectra Manager. The zero order absorption spectra were recorded over the wavelength range of 200-400 nm, against solvent blank, in quartz cuvetts with 1 cm diameter with scan speed of 100 nm/min and fixed value of slit width is 1 nm The ordinate maximum minimum were adjusted according to derivative values. 1.3.3 Development of UV first derivative Zero crossing method: As the Dutasteride is Insoluble in Water 80:20 V/V Mixture of Methanol and Water were used for method development First of all, Individual Zero orders absorption Spectra of both the drugs were recorded by scanning 10 ÃŽÂ ¼g/ml solution. The ÃŽÂ »max of Alfuzosin HCl and Dutasteride was found to be 240 nm 225.5 nm respectively. We have chosen derivative spectroscopy which is based on mathematical transformation of spectra zero order curves in to derivative spectra, which allows a fast sensitive and precise resolution of a multicomponent mixture and overcomes the problem of overlapping of a multi component system. Derivative Spectroscopy on the basis of zero crossing measurement involves measurement of absolute value of total derivative spectrum at an abscissa value corresponding to the Zero Crossing wavelength of the derivative spectra of individual components, which should be only the function of the concentration of the other component. Zero crossing points of Alfuzosin HCl a nd Dutasteride were identified in first derivative spectra. the measurement exhibited the best linear response and have given a near zero intercept on the coordinate of the calibration graph, and is less affected by the concentration of  any other component. Alfuzosin HCl was determined by measurement of its 1D amplitude at the zero-crossing point of Dutasteride was determined by measurement of its1 D at the zero-crossing point of Alfuzosin HCl . 1.3.4 Preparation of stock solution Primary standard stock solution of Alfuzosin HCl and Dutasteride were prepared separately by dissolving accurately weighed amount (10 mg) of drug in 10 ml 80:20 V/V (MeOH:H2O) to produce a concentration of 1.00mg/mL Working standard solution of each analyte were prepared by appropriate dilution of stock solution to get 100 ÃŽÂ ¼g/mL The further concentration required for constructing calibration curve were prepared daily by dilution of 100 ÃŽÂ ¼g/mL working standard. Stock solution of binary mixture was prepared by dissolving accurately weighed quantities of both drugs in solvent. Further dilutions of binary mixture were made to obtain QC samples. 1.3.5 Calibration standard quality control (QC) samples The standard calibration sample were prepared by diluting working standard solution of each analyte to yield seven different concentration over the range of  3-24 ÃŽÂ ¼g/mL for Alfuzosin HCl 3-30 ÃŽÂ ¼g/mL for Dutasteride . Linearity was evaluated separately for each drug using the defined analytical amplitudes (1D), with appropriate seven standard solutions. The QC sample were prepared from stock solution containing binary mixture to yield the low, medium high concentration (4,5 6ÃŽÂ ¼g/ml for Alfuzosin HCl) (20 ,25 30 ÃŽÂ ¼g/mLfor Dutasteride). 1.3.6 Procedure for calibration curve Absorption derivative spectra were recorded over the range of the wavelength range 200-400 nm. Zero order spectra of standard calibration sample of 10 ÃŽÂ ¼g/ml of each drug were recorded against blank. First order spectra were recorded with in concentration range, the value of analytical amplitude 1D231 and 1D250 for ATE LER respectively were recorded. The calibration curve for derivative spectrophotometry were constructed by plotting the drug concentration versus the absorbance values of the first derivative spectrum 1D at 1D 231 and 1D250 for ATE LER, respectively. 1.3.7 Inter-day Intra-day accuracy precision A QC standard prepared binary mixture was evaluated for Inter-day Intraday  accuracy precision. Accuracy was determined as the absolute value of the ratio of the back calculated mean values of QC to their respective nominal  values was expressed as percentage. Precision of assay was expressed as  percentage coefficient of variation (% CV) for QC sample Binary Mixture 1.3.8 Assay of Pharmaceutical dosage form A total number of 20 tablets (Alfusin D) accurately weighed and  powdered in a mortar. Quantities of the powdered tablets equivalent to 10 mg of Alfuzosin HCl 0.5 mg of Dutasteride were accurately weighed and transferred in to 100 ml volumetric flask. Weighed powder was dissolved in 80:20 V/V (MeOH:H2O) mixed thoroughly and kept under mechanical shaking for 15 minutes. Solution obtain was filtered through filter paper and diluted with same solvent to get the concentration within linearity and used for the measurement of derivative spectra. The concentration of Alfuzosin HCl and Dutasteride in tablet were calculated from corresponding calibration curve. 1.4 RESULTS AND DISCUSSION 1.4.1 Development of First derivative zero crossing method Derivative spectroscopy on the basis of zero crossing measurement involves measurement of absolute value of total derivative spectrum at an abscissa  value corresponding to the zero crossing wavelengths of the derivative spectra  of individual components. Which should be the function of the concentration of  other component Zero crossing points for ATE LER were found to be 211.9,  225.4, 250, 275.2, 292.2 218.4, 231, 240.7, 310.9, 362.7 nm respectively the  measurement at 250 231 exhibit best linear response. So ATE was  determined by measurement of its 1D amplitude at ZCP of LER (at 231 nm ). LER was determined by measurement of its 1D amplitude at ZCP of ATE (at  250 nm). 1.4.2 Validation23-25 1.4.2.1 Linearity Since beer law obeys between absorbance values 0.1-1, the linearity is  established by plotting points between these two readings in triplicate. for  Lercanidipine HCl linearity found to be between 3 ÃŽÂ ¼g/mL to 24 ÃŽÂ ¼g/mL with  typical regression equation of 0.0015x-0.0003 with regression coefficient of  0.9967 for Atenolol Linearity found to be between 3 ÃŽÂ ¼g/ml to 30 ÃŽÂ ¼g/ml with  regression equation 0.0025x+0.0005 with regression coefficient of 0.9996. 1.4.2.2 Accuracy The accuracy of method was established in triplicate in three consecutive days. At 80%, 100% 120% of the expected sample concentration in synthetic binary mixture, the method found to be very accurate with recovery References M. VAMSI KRISHNA* and D. GOWRI SANKAR Optimization and Validation of Quantitative Spectrophotometric Methods for the Determination of Alfuzosin in Pharmaceutical Formulations ISSN: 0973-4945; CODEN ECJHAO E-Journal of Chemistry Safwan Ashour, M. Fawaz Chehna, Roula Bayram Spectrophotometric Determination of Alfuzosin HCl in Pharmaceutical Formulations with some Sulphonephthalein Dyes International journal of Biomedical science M. SUGUMARAN Extractive Spectrophotometric Determination of Alfuzosin from Its Bulk and Pharmaceutical Dosage Form J. Ind. Council Chem. Vol. 26, No. 1, 2009, pp. 47-49 SYEDA HUMAIRA, AKALANKA DEY1, S APPALA RAJU, SYED SANAULLAH Applications Of Colorimetric Methods For The Determination Of Cinitapride Hydrogen Tartarate In Drug Formulations International Journal of Pharmacy and Pharmaceutical Sciences Vol 2, Suppl 1, 2010 Md Ruhul Amin, Moynul Hasan, Abdullah Al Masud, Md Hanif uddin,  Md Hasanuzzaman and Mohammad Kaisarul Islam Validated Uv Spectrophotometric Method For Estimation Of Dutasteride In Tablet Dosage Form Islam M K et al. / Pharmacie Globale (IJCP) 2011, 4 (04) Kamila M. M., Mondal N Ghosh L.K A Validated Spectrophotometric Method For  Determination Of Dutasteride In Bulk Drug And Pharmaceutical Formulations International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vishnu P. Choudhari*, Sacchidanand R. Gite, Rahul P. Raut, Asawaree A. Hable, Sanket R. Parekar, Bhanudas S. Kuchekar Spectrophotometric Simultaneous Determination Of Dutasteride And Tamsulosin In Combined Tablet Dosage Form By First Order Derivative Spectroscopy And Area Under Curve (Auc) Spectrophotometric Methods And Its Application To Uniformity Of Content In Tablet And Capsule ISSN 0976 -044 x Volume 2, Issue 2, May June 2010; Article 013

Sunday, January 19, 2020

cliques :: essays research papers

The purpose of my speech is to persuade that schools do not do enough to prevent harassment of other students. I.  Ã‚  Ã‚  Ã‚  Ã‚  In the movies you always see the big jock shoving the little dorky kid into a locker or pushing his head into a toilet. This doesn’t just happen in the movies, it can be a reality. A.  Ã‚  Ã‚  Ã‚  Ã‚  From recent statistics shown, 1 out of 4 kids have been or are being bullied, yet 1 out of 5 kids have said they have been a bully to someone. 1.  Ã‚  Ã‚  Ã‚  Ã‚  It’s hard to believe but 100,000 students carry a gun to school. I think that’s so disappointing for today’s youth that they have to carry a gun to feel safe. 2.  Ã‚  Ã‚  Ã‚  Ã‚  It’s not always students getting bullied; teachers are also assaulted, robbed, and etc. B.  Ã‚  Ã‚  Ã‚  Ã‚  People who are bullies know right away who to pick on. 1.  Ã‚  Ã‚  Ã‚  Ã‚  They are usually kids with not many friends also known as loners. 2.  Ã‚  Ã‚  Ã‚  Ã‚   Many people who are handicapped, mentally or physically are chosen to be harassed. C.  Ã‚  Ã‚  Ã‚  Ã‚  Teenage girls belonging to cliques can be very cruel if your appearance isn’t as stylish or trendy as they see fit. The girls will use insults, gossiping, rejection, or even spreading rumors. 1.  Ã‚  Ã‚  Ã‚  Ã‚  The self-esteem of the victims declines decreasingly low, making them think they are inferior. II.  Ã‚  Ã‚  Ã‚  Ã‚  Ronald Stephens, from the National School Safety Center says, â€Å"A lot of administrators don’t want a paper trail, it’s a fear of litigation and a reluctance to look bad.† A.  Ã‚  Ã‚  Ã‚  Ã‚  Some schools just ignore the fact that bullying is going on in the school. B.  Ã‚  Ã‚  Ã‚  Ã‚  Many parents have taken legal action because of the administrators who have done nothing about their harassment issues. III.  Ã‚  Ã‚  Ã‚  Ã‚  In Export Pennsylvania, Christina, a 7th grader was riding the bus home from school when two girls tried to light her hair on fire. A.  Ã‚  Ã‚  Ã‚  Ã‚  The school officials were contacted by Christina’s mother who reported the attack, yet the girls continued to harass Christina and her classmate Jessica. 1. They would shove and hit the girls in the halls, while the school still refused to do anything about the situation. 2.  Ã‚  Ã‚  Ã‚  Ã‚  The advice Christina and Jessica got from their Vice Principal was to keep a low profile until the bullies moved on to someone new. 3.  Ã‚  Ã‚  Ã‚  Ã‚  I think the Vice Principal has underestimated the magnititude of the situation. B.  Ã‚  Ã‚  Ã‚  Ã‚  It didn’t stop there though. The two girls had to be sent home because the school said they couldn’t guarantee their safety. 1.  Ã‚  Ã‚  Ã‚  Ã‚  The school board eventually got the girls a school aide to escort them to their classes.

Saturday, January 11, 2020

Introduction to Legal Research Essay

Facts: Samantha Smith, a young and single mother, was shopping in the bath aisle of the local grocery store in Indiana. At approximately 1:30 pm she slipped and fell on a clear shampoo that had leaked out of one of the bottles and onto the floor. The aisle had been inspected, logged as clear of any dangerous hazards at 1:00 pm by an older employee who requires glasses. As a result of the fall, Samantha was transported to the hospital where she was admitted overnight and diagnosed with a broken hip. She will require many months of physical therapy. Samantha has no healthcare insurance coverage to cover any of her expenses and is responsible for a two year old son. Issue: Did the grocery store have knowledge of the hazardous substance on the floor, therefore being held liable for the injuries that Samantha sustained? Rule: The grocery store can only be held liable if it had knowledge of the hazardous condition. Breach of duty is defined as â€Å"the violation of a legal or moral obligation; the failure to act as the law obligates one to act; especially a fiduciary’s violation of an obligation owed to another.† Black’s Law Dictionary 214 (9th ed. 2009) Negligence is defined as â€Å"the failure to exercise the standard of care that a reasonably prudent person would have exercised in a similar situation; any conduct that falls below the legal standard established to protect others against unreasonable risk of harm.† Black’s Law Dictionary 1133 (9th ed. 2009)  Analysis: Samantha is not able to prove that the grocery store had any knowledge of the hazardous substance on the floor; therefore, the grocery store was not negligent in its duty to the customer and cannot be held liable for Samantha’s injuries. Conclusion: It is not likely that Samantha will be awarded damages for her injuries because she cannot show proof that the grocery store had any knowledge of the hazardous spill on the floor. Vaughn v. National Tea Co., 328 F.2d 128 (7th Cir. 1964)  Facts: The Plaintiff, Vaughn, slipped and on a piece of lettuce and fell on the floor while shopping at National Tea Company. The store employee stated under testimony that she did not recall cleaning or picking up anything off of the aisle the day before the slip and fall occurred. The lettuce had multiple step marks on it which indicated that it had been there for a while. As a result of the slip and fall, Vaughn ruptured a disc in her back that resulted in the need for surgery. Vaughn filed a lawsuit against the National Tea Company for damages for the injuries she sustained. A jury found the Defendant guilty and awarded damages to Vaughn in the amount of $25,000. See more: how to write an introduction paragraph National Tea Company appealed the case stating there was no proof of negligence. Issue: Did National Tea Company have any knowledge of the lettuce on the floor which would ultimately hold them liable for the Vaughn’s injuries? Rule: Negligence is defined as â€Å"the failure to exercise the standard of care that a reasonably prudent person would have exercised in a similar situation; any conduct that falls below the legal standard established to protect others against unreasonable risk of harm.† Black’s Law Dictionary 1133 (9th ed. 2009) Evidence showed that the lettuce had been stepped on multiple times and, therefore, the jury could find that it was on the floor ample enough time for someone at the store to have a duty to clean it up. Analysis: The jury held that National Tea Company was negligent and a breach of duty occurred because they lettuce was on the floor for a long enough time period to be noticed and removed; therefore, Vaughn was awarded dama ges. Carmichael v. Kroger, 654 N.E.2d 1188 (Ind. Ct. App. 1995) Facts: Carmichael was shopping in the dairy aisle at Kroger and at approximately 2:00 pm slipped on a broken egg. As a result, Carmichael filed a lawsuit against Kroger for damages as a result of the slip and fall. Records show that a Kroger employee checked the dairy aisle just after 2:00 pm the same day and confirmed that there was no hazardous material on the floor. Carmichael was unable to prove to the Court that Kroger knew about the broken egg on the floor; therefore, Kroger was not found negligent or liable for Carmichael’s injuries. Issue: Did Kroger know about the broken egg on the floor which in turn would hold them liable for  Carmichael’s injuries? Rule: Liability cannot be imposed if Kroger was not aware of the broken egg on the floor. Negligence is defined as â€Å"the failure to exercise the standard of care that a reasonably prudent person would have exercised in a similar situation; any conduct that falls below the legal standard established to protect others against unreasonable risk of harm.† Black’s Law Dictionary 1133 (9th ed. 2009)  Analysis: Carmichael failed to prove to the Court that Kroger had any knowledge of the broken egg on the floor that created a hazard; therefore, Kroger was not negligent in its duty of care to Carmichael and cannot be held liable for Carmichael’s injuries. Conclusion: The Court of Appeals affirmed the lower court’s decision that Carmichael failed to prove negligence and breach of duty.

Friday, January 3, 2020

Nrs-433v Week 1 Literature Search Prevention of Surgical...

NRS-433V Week 1 Literature Search: Prevention of Surgical Site Infection To purchase this tutorial visit here: http://mindsblow.us/question_des/NRS-433VWeek1LiteratureSearchPreventionofSurgicalSiteInfection/2852 contact us at: help@mindblows.us NRS-433V Week 1 Literature Search: Prevention of Surgical Site Infection Details: Conduct a literature search to locate research articles focused on a practice problem of interest. This literature search should include both quantitative and qualitative peer research articles to support your practice problem or issue of interest in 350-750 words. Identify six peer research articles which will be utilized through the next 5 weeks as reference sources. Create a reference list in which the six†¦show more content†¦NRS-433V Week 1 Literature Search: Prevention of Surgical Site Infection To purchase this tutorial visit here: http://mindsblow.us/question_des/NRS-433VWeek1LiteratureSearchPreventionofSurgicalSiteInfection/2852 contact us at: help@mindblows.us NRS-433V Week 1 Literature Search: Prevention of Surgical Site Infection Details: Conduct a literature search to locate research articles focused on a practice problem of interest. This literature search should include both quantitative and qualitative peer research articles to support your practice problem or issue of interest in 350-750 words. Identify six peer research articles which will be utilized through the next 5 weeks as reference sources. Create a reference list in which the six articles are listed. Beneath each reference include the articles abstract. The completed assignment should have a title page and a reference list with abstracts. Suggestions for locating qualitative and quantitative research articles from credible sources: 1. Use a library database such as CINAHL Complete for your search. 2. Using the advanced search page check the box beside Research Article in the Limit Your Results section. 3. When setting up the search you can type your topic in the top box, then add quantitative or qualitative as a search term in one of the lower boxes. Research articles often are described as